Overview

  • Product nameAnti-MAPRE1 antibody
    See all MAPRE1 primary antibodies
  • Description
    Rabbit polyclonal to MAPRE1
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Rabbit, Goat, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 245-268 of Human MAPRE1 according to NP_036457.1.

  • Positive control
    • Human prostate carcinoma, and Mouse teratoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab117821 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. ab117821 can also be used for IHC-IF. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

Target

  • FunctionMay be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
  • Tissue specificityUbiquitously expressed.
  • Sequence similaritiesBelongs to the MAPRE family.
    Contains 1 CH (calponin-homology) domain.
    Contains 1 EB1 C-terminal domain.
  • DomainComposed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
  • Cellular localizationCytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5530600P05Rik antibody
    • Adenomatous polyposis coli binding protein EB 1 antibody
    • Adenomatous polyposis coli binding protein EB1 antibody
    • AI462499 antibody
    • AI504412 antibody
    • APC binding protein EB 1 antibody
    • APC binding protein EB1 antibody
    • APC-binding protein EB1 antibody
    • AW260097 antibody
    • BIM1p antibody
    • D2Ertd459e antibody
    • EB 1 antibody
    • EB1 antibody
    • End binding protein 1 antibody
    • End-binding protein 1 antibody
    • fa01e12 antibody
    • fc23e11 antibody
    • fi33c06 antibody
    • MAPRE 1 antibody
    • MAPRE1 antibody
    • Mapre3 antibody
    • MARE1_HUMAN antibody
    • MGC117374 antibody
    • MGC129946 antibody
    • MGC52508 antibody
    • Microtubule associated protein RP/EB family member 1 antibody
    • Microtubule-associated protein RP/EB family member 1 antibody
    • wu:fa01e12 antibody
    • wu:fc23e11 antibody
    • wu:fi33c06 antibody
    • zgc:55428 antibody
    • zgc:77807 antibody
    • zgc:85755 antibody
    see all

Anti-MAPRE1 antibody images

  • Detection of Human MAPRE1 by Immunohistochemistry. Sample: Formalin Fixed Paraffin Embedded section of Human prostate carcinoma. Antibody: ab117821 used at a dilution of 1/100. Detection: Red-fluorescent Goat anti-Rabbit IgG heavy and light chain cross-adsorbed Antibody DyLight 594 Conjugated used at a dilution of 1/100.
  • Immunohistochemical detection of Human MAPRE1 in paraffin embedded formalin fixed Human prostate carcinoma tissue section using 1/250 ab117821. DAB detection.
  • Immunohistochemical detection of Mouse MAPRE1 in paraffin embedded formalin fixed Mouse teratoma tissue section using 1/250 ab117821. DAB detection.

References for Anti-MAPRE1 antibody (ab117821)

This product has been referenced in:
  • Patel DM  et al. Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions. J Cell Biol 206:779-97 (2014). Read more (PubMed: 25225338) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"