ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
Use at an assay dependent concentration.
FunctionMay be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
Tissue specificityUbiquitously expressed.
Sequence similaritiesBelongs to the MAPRE family. Contains 1 CH (calponin-homology) domain. Contains 1 EB1 C-terminal domain.
DomainComposed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
Cellular localizationCytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome.
Adenomatous polyposis coli binding protein EB 1 antibody
Adenomatous polyposis coli binding protein EB1 antibody
APC binding protein EB 1 antibody
APC binding protein EB1 antibody
APC-binding protein EB1 antibody
EB 1 antibody
End binding protein 1 antibody
End-binding protein 1 antibody
MAPRE 1 antibody
Microtubule associated protein RP/EB family member 1 antibody
Microtubule-associated protein RP/EB family member 1 antibody
Anti-MAPRE1 antibody [KT51] images
Immunocytochemistry/ Immunofluorescence - Anti-MAPRE1 antibody [KT51] (ab53358)Image courtesy of an abreview submitted by Dr. Kirk McManus
ab53358 staining MAPRE1 in Hela cells (red). Cells were fixed in methanol, permeabilised with 0.5% Triton X100/ PBS and counterstained both with DAPI - to highlight the nucleus (blue) - and an anti-tubulin antibody (green). Please refer to abreview for further experimental details.