Overview

  • Product name
  • Description
    Rabbit polyclonal to MARCH4
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Horse, Chicken, Dog, Human, Chimpanzee, Zebrafish
  • Immunogen

    Synthetic peptide, corresponding to a portion of the amino acids 300-350 of Human MARCH4

  • Positive control
    • Liver tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab78005 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 46 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Relevance
    MARCH4, an E3 ubiquitin protein ligase, may mediate ubiquitination of MHC I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin protein ligases accept ubiquitin from an E2 ubiquitin conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
  • Cellular localization
    Golgi apparatus membrane; Multipass membrane protein.
  • Database links
  • Alternative names
    • BC056494 antibody
    • E3 ubiquitin protein ligase MARCH4 antibody
    • KIAA1399 antibody
    • MARCH 4 antibody
    • MARCH IV antibody
    • Membrane associated RING CH protein IV antibody
    • Membrane associated ring finger (C3HC4) 4 antibody
    • Membrane associated RING finger protein 4 antibody
    • MGC104908 antibody
    • mKIAA1399 antibody
    • RING finger protein 174 antibody
    • RNF174 antibody
    see all

Images

  • ab78005, at 5µg/ml, staining MARCH4 in liver tissue by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

References

ab78005 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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