Overview

  • Product nameAnti-MARCH9 antibody
    See all MARCH9 primary antibodies
  • Description
    Rabbit polyclonal to MARCH9
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within the internal sequence amino acids 287-336 (SRTGPTSGAT SRPPAAQRMR TLLPQRCGYT ILHLLGQLRP PDARSSSHSG) of Human MARCH9 (NP_612405).

  • Positive control
    • ACHN cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab99231 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceMARCH9 (membrane-associated RING-CH protein IX) belongs to MARCH family, which contains at least seven membrane-associated RING-CH (MARCH)proteins. All MARCH proteins are ubiquitin ligases and located to subcellular membranes, and several MARCH proteins reduce surface levels of known substrates of the viral K3 family. Two closely related proteins, MARCH-IV and MARCH-IX, reduce surface expression of MHC-I molecules. In the presence of MARCH-IV or MARCH-IX, MHC-I are ubiquitinated and rapidly internalized by endocytosis. The functional similarity of the MARCH family and the K3 family of viral immune evasion proteins suggests that the viral immune evasion proteins were derived from MARCH proteins, a novel family of transmembrane ubiquitin ligases that seems to target glycoproteins for lysosomal destruction via ubiquitination of the cytoplasmic tail.
  • Cellular localizationGolgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
  • Database links
  • Alternative names
    • BC019560 antibody
    • E3 ubiquitin protein ligase MARCH9 antibody
    • FLJ36578 antibody
    • MARCH IX antibody
    • Membrane associated RING CH protein IX antibody
    • membrane associated ring finger (C3HC4) 9 antibody
    • Membrane associated RING finger protein 9 antibody
    • RING finger protein 179 antibody
    • RNF179 antibody
    see all

Anti-MARCH9 antibody images

  • Anti-MARCH9 antibody (ab99231) at 1 µg/ml + ACHN cell lysate at 10 µg

    Predicted band size : 38 kDa

References for Anti-MARCH9 antibody (ab99231)

ab99231 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"