FunctionRole in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection.
Tissue specificityHigh levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.
Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily. Contains 1 KA1 (kinase-associated) domain. Contains 1 protein kinase domain. Contains 1 UBA domain.
Cellular localizationCell membrane. Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane.
1 mg whole cell lysate from 293T cells was immunoprecipitated using Lane 1: ab113267 at 6 µg/mg lysate Lane 2: a Rabbit anti-MARK2 antibody that recognizes a downstream epitope
Lane 3: a control IgG. 20% of immunoprecipitates was loaded on the gel. For WB of immunoprecipitated MARK2, ab113267 was used at 1 µg/ml. Detection:
Chemiluminescence with an exposure time of 30 seconds.
References for Anti-MARK2 antibody (ab113267)
has not yet been referenced specifically in any publications.
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