Anti-MASS1 antibody (ab115621)

Overview

• Product nameAnti-MASS1 antibody
  See all MASS1 primary antibodies
• Description
  Rabbit polyclonal to MASS1
• Tested applicationsSuitable for: IHC-Pmore details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide derived from the N terminal extracellular domain of Human MASS1.

• Positive control
  • Human Brain cortex and Lung (respiratory epithelium) tissues.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at -80°C.
• Storage bufferPreservative: 0.1% Sodium azide
  Constituent: 99% PBS
• Concentration information loading...
• PurityProtein A purified
• ClonalityPolyclonal
• IsotypeIgG
• Research areas
  • Neuroscience
  • Neurotransmission
  • Receptors / Channels
  • GPCR
  • More GPCR

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Brain (human): cerebral cortex normal tissue slides (ab4296)
  • Lung (human) normal tissue slides (ab4349)

Applications

Target

• FunctionReceptor that may have an important role in the development of the central nervous system.
• Tissue specificityExpressed at low levels in adult tissues.
• Involvement in diseaseDefects in GPR98 are the cause of Usher syndrome type 2C (USH2C) [MIM:605472]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses.
  Defects in GPR98 may be a cause of familial febrile convulsions type 4 (FEB4) [MIM:604352]; also known as familial febrile seizures 4. Febrile convulsions are seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.
• Sequence similaritiesBelongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
  Contains 35 Calx-beta domains.
  Contains 6 EAR repeats.
  Contains 1 GPS domain.
• Developmental stageIsoform 1 is 4 times more abundant than isoform 2 in most tissues tested, despite wide variations in absolute levels of expression. Isoform 3 is expressed at about 1.5 times isoform 1 levels in most tissues examined. In fetal testis, isoform 3 is expressed almost exclusively.
• Cellular localizationCell membrane.

• Target information above from: UniProt accession Q8WXG9 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 84059 Human
  • Omim: 602851 Human
  • SwissProt: Q8WXG9 Human
  • Unigene: 591777 Human
• Alternative names
  • DKFZp761P0710 antibody
  • FEB 4 antibody
  • FEB4 antibody

  • G protein coupled receptor 98 antibody
  • G-protein coupled receptor 98 antibody
  • GPR 98 antibody
  • GPR98 antibody
  • GPR98_HUMAN antibody
  • KIAA0686 antibody
  • MASS 1 antibody
  • Monogenic audiogenic seizure susceptibility 1 homolog antibody
  • Monogenic audiogenic seizure susceptibility protein 1 homolog antibody
  • USH 2B antibody
  • USH 2C antibody
  • USH2B antibody
  • USH2C antibody
  • Usher syndrome 2C antibody
  • Usher syndrome type 2C protein antibody
  • Usher syndrome type-2C protein antibody
  • Very large G protein coupled receptor antibody
  • Very large G protein coupled receptor 1 antibody
  • Very large G-protein coupled receptor 1 antibody
  • VLGR 1 antibody
  • VLGR 1b antibody
  • VLGR1 antibody
  • VLGR1b antibody

  see all