• Product nameAnti-Matriptase 2 antibody
    See all Matriptase 2 primary antibodies
  • Description
    Rabbit polyclonal to Matriptase 2
  • Specificityab28287 recognises the stem region of Matriptase 2. It does not react with the free enzyme. It does not recognise Matriptase 1.
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to the stem region of human Matriptase 2.

    (Peptide available as ab41267.)



Our Abpromise guarantee covers the use of ab28287 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 89 kDa. EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen.
ICC/IF Use a concentration of 1 µg/ml.


  • FunctionSerine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter.
  • Tissue specificityLiver specific.
  • Involvement in diseaseDefects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA) [MIM:206200]; also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 2 CUB domains.
    Contains 3 LDL-receptor class A domains.
    Contains 1 peptidase S1 domain.
  • DomainCytoplasmic domain mediates HAMP suppression via proximal promoter element(s).
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • IRIDA antibody
    • Matriptase-2 antibody
    • Membrane bound mosaic serine proteinase matriptase 2 antibody
    • Membrane type serine proteinase 2 antibody
    • MTSP 2 antibody
    • MTSP2 antibody
    • PVAE354 antibody
    • TMPRSS 6 antibody
    • TMPRSS6 antibody
    • TMPS6_HUMAN antibody
    • TMSP 6 antibody
    • TMSP6 antibody
    • Transmembrane protease serine 6 antibody
    • Type II Membrane Serine Proteinase 6 antibody
    see all

Anti-Matriptase 2 antibody images

  • ICC/IF image of ab28287 stained Hek293 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab28287, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

References for Anti-Matriptase 2 antibody (ab28287)

This product has been referenced in:
  • Gnana-Prakasam JP  et al. Retinal expression of the serine protease matriptase-2 (Tmprss6) and its role in retinal iron homeostasis. Mol Vis 20:561-74 (2014). Mouse . Read more (PubMed: 24791141) »

See 1 Publication for this product

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