• Product nameAnti-Matriptase 2 antibody
    See all Matriptase 2 primary antibodies
  • Description
    Rabbit polyclonal to Matriptase 2
  • Specificityab56181 reacts with human Matripase 2 (TMPRSS6), and does not react with the other TMPRSSs. ab56181 recognizes all but the two truncated forms of Matripase 2.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Matriptase 2. Synthetic peptide based on the CUB-2 domain of Matripase 2.



Our Abpromise guarantee covers the use of ab56181 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: 1/1000 when using colorimetric substrates such as BCIP/NBT, and 1/5000 for chemiluminescent substrates. Predicted molecular weight: 89 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionSerine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter.
    • Tissue specificityLiver specific.
    • Involvement in diseaseDefects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA) [MIM:206200]; also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.
    • Sequence similaritiesBelongs to the peptidase S1 family.
      Contains 2 CUB domains.
      Contains 3 LDL-receptor class A domains.
      Contains 1 peptidase S1 domain.
    • DomainCytoplasmic domain mediates HAMP suppression via proximal promoter element(s).
    • Cellular localizationCell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • IRIDA antibody
      • Matriptase-2 antibody
      • Membrane bound mosaic serine proteinase matriptase 2 antibody
      • Membrane type serine proteinase 2 antibody
      • MTSP 2 antibody
      • MTSP2 antibody
      • PVAE354 antibody
      • TMPRSS 6 antibody
      • TMPRSS6 antibody
      • TMPS6_HUMAN antibody
      • TMSP 6 antibody
      • TMSP6 antibody
      • Transmembrane protease serine 6 antibody
      • Type II Membrane Serine Proteinase 6 antibody
      see all

    Anti-Matriptase 2 antibody images

    • All lanes : Anti-Matriptase 2 antibody (ab56181) at 1/1000 dilution

      Lane 1 : Cell media from human embryonic kidney HEK293 cells
      Lane 2 : Cell media from human embryonic kidney HEK293 cells
      Lane 3 : Cell media from human embryonic kidney HEK293 cells

      Predicted band size : 89 kDa

    References for Anti-Matriptase 2 antibody (ab56181)

    ab56181 has not yet been referenced specifically in any publications.

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