Overview

  • Product name
    Anti-Matriptase 2 antibody
    See all Matriptase 2 primary antibodies
  • Description
    Rabbit polyclonal to Matriptase 2
  • Specificity
    ab56181 reacts with human Matripase 2 (TMPRSS6), and does not react with the other TMPRSSs. ab56181 recognizes all but the two truncated forms of Matripase 2.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Matriptase 2. Synthetic peptide based on the CUB-2 domain of Matripase 2.

Properties

Applications

Our Abpromise guarantee covers the use of ab56181 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/1000 when using colorimetric substrates such as BCIP/NBT, and 1/5000 for chemiluminescent substrates. Predicted molecular weight: 89 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter.
    • Tissue specificity
      Liver specific.
    • Involvement in disease
      Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA) [MIM:206200]; also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.
    • Sequence similarities
      Belongs to the peptidase S1 family.
      Contains 2 CUB domains.
      Contains 3 LDL-receptor class A domains.
      Contains 1 peptidase S1 domain.
    • Domain
      Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s).
    • Cellular localization
      Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • IRIDA antibody
      • Matriptase-2 antibody
      • Membrane bound mosaic serine proteinase matriptase 2 antibody
      • Membrane type serine proteinase 2 antibody
      • MTSP 2 antibody
      • MTSP2 antibody
      • PVAE354 antibody
      • TMPRSS 6 antibody
      • TMPRSS6 antibody
      • TMPS6_HUMAN antibody
      • TMSP 6 antibody
      • TMSP6 antibody
      • Transmembrane protease serine 6 antibody
      • Type II Membrane Serine Proteinase 6 antibody
      see all

    Images

    • All lanes : Anti-Matriptase 2 antibody (ab56181) at 1/1000 dilution

      Lane 1 : Cell media from human embryonic kidney HEK293 cells
      Lane 2 : Cell media from human embryonic kidney HEK293 cells
      Lane 3 : Cell media from human embryonic kidney HEK293 cells


      Predicted band size : 89 kDa

    References

    ab56181 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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