Overview

  • Product name
  • Description
    Rabbit polyclonal to MAVS
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region between C terminal amino acids 476-505 of Human MAVS (NP_065797.2).

  • Positive control
    • HeLa cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab116545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 57 kDa.

Target

  • Function
    Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
  • Tissue specificity
    Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
  • Sequence similarities
    Contains 1 CARD domain.
  • Domain
    Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58 and IFIH1.
  • Post-translational
    modifications
    Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS proteasomal degradation.
  • Cellular localization
    Mitochondrion outer membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CARD adapter inducing interferon beta antibody
    • CARD adaptor inducing IFN beta antibody
    • Cardif antibody
    • DKFZp666M015 antibody
    • FLJ27482 antibody
    • FLJ41962 antibody
    • IFN B promoter stimulator 1 antibody
    • Interferon beta promoter stimulator protein 1 antibody
    • Ips 1 antibody
    • IPS-1 antibody
    • Ips1 antibody
    • KIAA1271 antibody
    • MAVS antibody
    • MAVS_HUMAN antibody
    • Mitochondrial anti viral signaling protein antibody
    • Mitochondrial Antiviral Signaling antibody
    • Mitochondrial antiviral signaling protein antibody
    • Mitochondrial antiviral-signaling protein antibody
    • Putative NF kappa B activating protein 031N antibody
    • Putative NF-kappa-B-activating protein 031N antibody
    • Virus induced signaling adapter antibody
    • virus induced signaling adaptor antibody
    • Virus-induced-signaling adapter antibody
    • VISA antibody
    see all

Images

  • Anti-MAVS antibody (ab116545) at 1/100 dilution + HeLa cell line lysates at 35 µg

    Predicted band size : 57 kDa

References

ab116545 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab116545.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up