Overview

  • Product name
  • Description
    Rabbit polyclonal to MAVS
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to a region between residues 250 and 300 of human MAVS (AAH44952.1).

  • Positive control
    • HeLa whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab70825 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP
  • Application notes
    IP: Use at 2-5µg/mg of lysate.


    Is unsuitable for WB.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
    • Tissue specificity
      Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
    • Sequence similarities
      Contains 1 CARD domain.
    • Domain
      Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58 and IFIH1.
    • Post-translational
      modifications
      Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS proteasomal degradation.
    • Cellular localization
      Mitochondrion outer membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CARD adapter inducing interferon beta antibody
      • CARD adaptor inducing IFN beta antibody
      • Cardif antibody
      • DKFZp666M015 antibody
      • FLJ27482 antibody
      • FLJ41962 antibody
      • IFN B promoter stimulator 1 antibody
      • Interferon beta promoter stimulator protein 1 antibody
      • Ips 1 antibody
      • IPS-1 antibody
      • Ips1 antibody
      • KIAA1271 antibody
      • MAVS antibody
      • MAVS_HUMAN antibody
      • Mitochondrial anti viral signaling protein antibody
      • Mitochondrial Antiviral Signaling antibody
      • Mitochondrial antiviral signaling protein antibody
      • Mitochondrial antiviral-signaling protein antibody
      • Putative NF kappa B activating protein 031N antibody
      • Putative NF-kappa-B-activating protein 031N antibody
      • Virus induced signaling adapter antibody
      • virus induced signaling adaptor antibody
      • Virus-induced-signaling adapter antibody
      • VISA antibody
      see all

    References

    ab70825 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab70825.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up