The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human Maxi K+ beta, catalog ab5023. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
BK channel beta subunit
BK channel subunit beta 1
Calcium activated potassium channel subfamily M subunit beta 1
Large conductance Ca2+ activated K+ channel beta 1 subunit
Maxi K channel beta subunit
Maxi K channel subunit beta 1
Potassium large conductance calcium activated channel subfamily M beta member 1
Slo beta 1
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits.
Membrane; multi-pass membrane protein
This product has been referenced in:
Navarro-Antolín J et al. Decreased expression of maxi-K+ channel beta1-subunit and altered vasoregulation in hypoxia. Circulation112:1309-15 (2005).
Read more (PubMed: 16116057) »