MBD2 Binding Activity Quantification Assay Kit (ab113473)

Overview

  • Product nameMBD2 Binding Activity Quantification Assay Kit
  • Assay time
    3h 00m
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: all Mammals
  • Product overview

    MBD2 (methyl-CpG binding domain protein 2) belongs to a family of MBD domain containing proteins. This family of proteins associates with heterochromatin by their interaction with methylated DNA at CpG islands, and appear to 'read' and 'translate' the DNA methylation signal into transcriptional repression by recruiting silencing complexes and histone deacetylases among other proteins. MBD2 is the methyl-binding component of the MeCP1 complex, which allows MBD2 to target HDAC/chromatin remodeling activity to methylated templates.

     MBD2 Binding Activity Quantification Assay Kit (ab113473) allows the user to measure binding activity of MBD2 to methylated DNA in human cells/tissues. It can also be used to determine inhibitors of MBD2 activity.

  • Tested applicationsFunctional Studiesmore details

Properties

    Applications

    Our Abpromise guarantee covers the use of ab113473 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    Protocols

    References for MBD2 Binding Activity Quantification Assay Kit (ab113473)

    ab113473 has not yet been referenced specifically in any publications.

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    The immunogen sequence used to raise the antibody in this kit is proprietary information. However, in order to aid your research I am able to inform you that it has been raised against...

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