Overview

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab103144 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 160 kDa.

Target

  • FunctionBinds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
  • Tissue specificityDetected in heart, placenta, liver, skeletal muscle, kidney and pancreas.
  • Involvement in diseaseDefects in MBD5 are the cause of mental retardation autosomal dominant type 1 (MRD1) [MIM:156200]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
  • Sequence similaritiesContains 1 MBD (methyl-CpG-binding) domain.
    Contains 1 PWWP domain.
  • DomainBoth MBD and PWWP domains are necessary for chromocentric localization.
  • Cellular localizationNucleus. Chromosome. Associated with pericentric heterochromatin and Nucleus. Not associated with pericentric heterochromatin.
  • Information by UniProt
  • Database links
  • Alternative names
    • 9430004D19Rik antibody
    • AA536666 antibody
    • AI426407 antibody
    • C030040A15Rik antibody
    • FLJ11113 antibody
    • FLJ30517 antibody
    • KIAA1461 antibody
    • MBD5 antibody
    • MBD5_HUMAN antibody
    • methyl CpG binding domain protein 5 antibody
    • Methyl CpG binding protein MBD5 antibody
    • Methyl-CpG-binding domain protein 5 antibody
    • Methyl-CpG-binding protein MBD5 antibody
    • RP23 167N13.1 antibody
    see all

Anti-MBD5 antibody images

  • Anti-MBD5 antibody (ab103144) at 5 µg/ml + Human liver lysate at 50 µg

    Predicted band size : 160 kDa
  • Anti-MBD5 antibody (ab103144) at 5 µg/ml + HepG2 cell lysate at 50 µg

    Predicted band size : 160 kDa

References for Anti-MBD5 antibody (ab103144)

ab103144 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting Abcam regarding ab103144.


Regarding the immunogen sequence, the antibody was raised against aa623-840 of MBD5. The sequence can be found in UniProt entry Q9P267.

MFPPTANMLLPTGEGQSGRAALRDKLMSQQKDALRKRKQPPT...

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Thank you for bringing this to our attention.

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