Overview

  • Product name
    Anti-MC1 Receptor antibody
    See all MC1 Receptor primary antibodies
  • Description
    Rabbit polyclonal to MC1 Receptor
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within amino acids 253 and 317 (CWGPFFLHLT LIVLCPEHPT CGCIFKNFNL FLALIICNAI IDPLIYAFHS QELRRTLKEV LTCSW) of Human MC1 Receptor (NP_002377)

  • Positive control
    • Molt4 whole cell lysate; 293T, HeLa and Raji cells

Properties

Applications

Our Abpromise guarantee covers the use of ab97321 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 35 kDa.

Target

  • Function
    Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
  • Tissue specificity
    Melanocytes and corticoadrenal tissue.
  • Involvement in disease
    Genetic variations in MC1R are a cause of susceptibility to cutaneous malignant melanoma type 5 (CMM5) [MIM:613099]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CMM5 antibody
    • MC1-R antibody
    • MC1R antibody
    • Melanocortin 1 receptor antibody
    • Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) antibody
    • Melanocortin receptor 1 antibody
    • Melanocyte-stimulating hormone receptor antibody
    • Melanotropin receptor antibody
    • MSH-R antibody
    • MSHR antibody
    • MSHR_HUMAN antibody
    • SHEP2 antibody
    see all

Images

  • Anti-MC1 Receptor antibody (ab97321) at 1/1000 dilution + Molt4 whole cell lysate at 30 µg

    Predicted band size : 35 kDa

References

This product has been referenced in:
  • Simamura E  et al. Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. PLoS One 10:e0123232 (2015). Read more (PubMed: 25860801) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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