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Rabbit monoclonal [EPR6530] to MC1 Receptor
IHC-P more details Unsuitable for:
Flow Cyt,ICC or IP
A synthetic peptide corresponding to residues in Human MC1 Receptor.
WB: A375 and Human melanoma lysates
IHC-P: Human melanoma tissue
This product is a recombinant rabbit monoclonal antibody.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab ® patents
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Dissociation constant (K
Preservative: 0.01% Sodium azide Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Tissue culture supernatant
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000 - 1/10000. Predicted molecular weight: 35 kDa.
1/500 - 1/1000. Antigen retrieval is not essential but may optimise staining.
Is unsuitable for Flow Cyt,ICC or IP.
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Melanocytes and corticoadrenal tissue.
Involvement in disease
Genetic variations in MC1R are a cause of susceptibility to cutaneous malignant melanoma type 5 (CMM5) [MIM:613099]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
Belongs to the G-protein coupled receptor 1 family.
Information by UniProt
Western blot - Anti-MC1 Receptor antibody [EPR6530] (ab125031)
All lanes : Anti-MC1 Receptor antibody [EPR6530] (ab125031) at 1/1000 dilution Lane 1 : A375 cell lysate Lane 2 : Human melanoma lysate Lysates/proteins at 10 µg per lane. Secondary HRP labelled goat anti rabbit at 1/2000 dilution Predicted band size : 35 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MC1 Receptor antibody [EPR6530] (ab125031)
ab125031, at a 1/500 dilution, staining MC1 Receptor in paraffin embedded Human melanoma tissue by Immunohistochemistry.
Other-Anti-MC1 Receptor antibody [EPR6530](ab125031)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"