1/500 - 1/1000. Antigen retrieval is not essential but may optimise staining.
Is unsuitable for Flow Cyt,ICC or IP.
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Melanocytes and corticoadrenal tissue.
Involvement in disease
Genetic variations in MC1R are a cause of susceptibility to cutaneous malignant melanoma type 5 (CMM5) [MIM:613099]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
Belongs to the G-protein coupled receptor 1 family.