Anti-MC2 receptor antibody (ab125398)


  • Product name
    Anti-MC2 receptor antibody
    See all MC2 receptor primary antibodies
  • Description
    Rabbit polyclonal to MC2 receptor
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 86-135 (LRNMGYLKPR GSFETTADDI IDSLFVLSLL GSIFSLSVIA ADRYITIFHA) of Human MC2 Receptor (NP_000520.1).

  • Positive control
    • Human fetal kidney lysate.



Our Abpromise guarantee covers the use of ab125398 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 34 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function
    Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.
  • Tissue specificity
    Melanocytes and corticoadrenal tissue.
  • Involvement in disease
    Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACTH receptor antibody
    • ACTH-R antibody
    • ACTHR antibody
    • ACTHR_HUMAN antibody
    • Adrenocorticotropic hormone receptor antibody
    • Adrenocorticotropin receptor antibody
    • Corticotropin receptor antibody
    • MC2 receptor antibody
    • MC2-R antibody
    • MC2R antibody
    • Melanocortin 2 receptor (adrenocorticotropic hormone) antibody
    • Melanocortin 2 receptor antibody
    • Melanocortin receptor 2 antibody
    see all

Anti-MC2 receptor antibody images

  • Anti-MC2 receptor antibody (ab125398) at 1 µg/ml + Human fetal kidney lysate at 10 µg

    Predicted band size : 34 kDa

References for Anti-MC2 receptor antibody (ab125398)

ab125398 has not yet been referenced specifically in any publications.

Product Wall

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this...

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I agree that if you are not seeing anything between 30 and 40 kDa then the antibody is probably the issue, and not the sample preparation. If you want to try ab77347 as a free-of-charge replacement for ab125398 (you do not need to send back the remaind...

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Thank you for completing our troubleshooting form. Your protocol looks correct. My one concern is that the receptor may be aggregating when you heat the samples to 95C. MC2R, like other multi-pass membrane receptors, tends to form aggregates when boile...

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