Anti-MC2 receptor antibody (ab77347)

Overview

  • Product name
    Anti-MC2 receptor antibody
    See all MC2 receptor primary antibodies
  • Description
    Goat polyclonal to MC2 receptor
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Sheep, Horse, Cow, Dog, Chimpanzee
  • Immunogen

    Synthetic peptide:

    ENINNTARNNSDC

    , corresponding to N terminal amino acids 9-21 of Human MC2 receptor (NP_000520.1)

  • Positive control
    • Human skin lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab77347 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    Peptide ELISA: Antibody detection limit dilution: 1/32000.
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 34 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.
    • Tissue specificity
      Melanocytes and corticoadrenal tissue.
    • Involvement in disease
      Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.
    • Sequence similarities
      Belongs to the G-protein coupled receptor 1 family.
    • Cellular localization
      Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • ACTH receptor antibody
      • ACTH-R antibody
      • ACTHR antibody
      • ACTHR_HUMAN antibody
      • Adrenocorticotropic hormone receptor antibody
      • Adrenocorticotropin receptor antibody
      • Corticotropin receptor antibody
      • MC2 receptor antibody
      • MC2-R antibody
      • MC2R antibody
      • Melanocortin 2 receptor (adrenocorticotropic hormone) antibody
      • Melanocortin 2 receptor antibody
      • Melanocortin receptor 2 antibody
      see all

    Images

    References

    ab77347 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Vielen Dank für Ihren Anruf von gestern. Leider habe ich keine Referenzen zu diesen Antikörpern gefunden. Es tut mir leid.

    Es freut mich zu hören, dass Sie unser Angebot unseren Antikörper ab77347 in Immunohistochemie auf Paraffinschnitten z...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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