Anti-MC2 receptor antibody (ab77347)

Overview

  • Product nameAnti-MC2 receptor antibody
    See all MC2 receptor primary antibodies
  • Description
    Goat polyclonal to MC2 receptor
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Sheep, Horse, Cow, Dog, Chimpanzee
  • Immunogen

    Synthetic peptide:

    ENINNTARNNSDC

    , corresponding to N terminal amino acids 9-21 of Human MC2 receptor (NP_000520.1)

  • Positive control
    • Human skin lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab77347 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notesPeptide ELISA: Antibody detection limit dilution: 1/32000.
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 34 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionReceptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.
    • Tissue specificityMelanocytes and corticoadrenal tissue.
    • Involvement in diseaseDefects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.
    • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
    • Cellular localizationCell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • ACTH receptor antibody
      • ACTH-R antibody
      • ACTHR antibody
      • ACTHR_HUMAN antibody
      • Adrenocorticotropic hormone receptor antibody
      • Adrenocorticotropin receptor antibody
      • Corticotropin receptor antibody
      • MC2 receptor antibody
      • MC2-R antibody
      • MC2R antibody
      • Melanocortin 2 receptor (adrenocorticotropic hormone) antibody
      • Melanocortin 2 receptor antibody
      • Melanocortin receptor 2 antibody
      see all

    Anti-MC2 receptor antibody images

    References for Anti-MC2 receptor antibody (ab77347)

    ab77347 has not yet been referenced specifically in any publications.

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