Overview

  • Product name
    Anti-MCAF1 antibody [2052C2a]
    See all MCAF1 primary antibodies
  • Description
    Mouse monoclonal [2052C2a] to MCAF1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment (Human), amino acids 50-200.

Properties

Applications

Our Abpromise guarantee covers the use of ab50956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Detects a band of approximately 40 kDa (predicted molecular weight: 136 kDa).

Target

  • Relevance
    MCAF1 is a recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. It can act both as an activator or a repressor depending on the context. It mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. MCAF1 is required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9'. The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation.
  • Cellular localization
    Nuclear
  • Database links
  • Alternative names
    • Activating transcription factor 7 interacting protein 1 antibody
    • ATF interacting protein antibody
    • ATF IP antibody
    • ATF7IP antibody
    • ATFa associated modulator antibody
    • FLJ10139 antibody
    • FLJ10688 antibody
    • hAM antibody
    • HGNC:20092 antibody
    • MBD1 containing chromatin associated factor antibody
    • MCAF 1 antibody
    • MCAF antibody
    • p621 antibody
    see all

Images

References

ab50956 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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