Overview

  • Product name
  • Description
    Rabbit polyclonal to MCC
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-316 of Human MCC (P23508).

  • Positive control
    • IMR32 and U-87 MG whole cell lysates; Human Colon carcinoma tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 78% PBS, 20% Glycerol, 1% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab125920 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 93 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation.
  • Tissue specificity
    Expressed in a variety of tissues.
  • Sequence similarities
    Belongs to the MCC family.
  • Cellular localization
    Cell membrane. Nucleus. Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Colorectal mutant cancer protein antibody
    • CRCM_HUMAN antibody
    • DKFZp762O1615 antibody
    • FLJ38893 antibody
    • FLJ46755 antibody
    • MCC 1 antibody
    • MCC antibody
    • MCC1 antibody
    • Mutated in colorectal cancers antibody
    • Protein MCC antibody
    see all

Images

  • Anti-MCC antibody (ab125920) at 1/1000 dilution + IMR32 whole cell lysate at 30 µg

    Predicted band size : 93 kDa
  • ab125920, at 1/250 dilution, staining MCC in Paraffin-embedded Human Colon carcinoma tissue by immunohistochemistry.

References

ab125920 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab125920.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up