• Product nameAnti-MCFD2 antibody
    See all MCFD2 primary antibodies
  • Description
    Mouse monoclonal to MCFD2
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-147 of Human MCFD2


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2a
  • Light chain typekappa
  • Research areas


Our Abpromise guarantee covers the use of ab57843 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionThe MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
    • Involvement in diseaseDefects in MCFD2 are a cause of factor V and factor VIII combined deficiency type 2 (F5F8D2) [MIM:613625]; also known as multiple coagulation factor deficiency 2 (MCFD2). F5F8D2 is a blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.
    • Sequence similaritiesContains 2 EF-hand domains.
    • DomainEssentially unstructured in the absence of calcium ions. Requires calcium ions for folding.
    • Cellular localizationEndoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 1810021C21Rik antibody
      • DKFZp686G21263 antibody
      • F5F8D antibody
      • LMAN1IP antibody
      • MCFD 2 antibody
      • Mcfd2 antibody
      • MCFD2_HUMAN antibody
      • Multiple coagulation factor deficiency protein 2 antibody
      • Neural stem cell derived neuronal survival protein antibody
      • Neural stem cell-derived neuronal survival protein antibody
      • SDNSF antibody
      see all

    Anti-MCFD2 antibody images

    • MCFD2 antibody (ab57843) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human ovary, clear cell carcinoma.
    • Western blot against tagged recombinant protein immunogen using ab57843 MCFD2 antibody at 1ug/ml. Predicted band size of immunogen is 42 kDa

    References for Anti-MCFD2 antibody (ab57843)

    ab57843 has not yet been referenced specifically in any publications.

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