Overview

  • Product name
  • Description
    Rabbit polyclonal to MCK10
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow, Pig, Monkey
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 581-795 of Human MCK10 (Uniprot ID: Q08345).

  • Positive control
    • THP1 whole cell lysate; BT474 xenograft
  • General notes
    Keep as a concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab155508 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/300. Predicted molecular weight: 101 kDa.
IHC-P 1/100 - 1/1000. Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).

Target

  • Function
    May be involved in cell-cell interactions and recognition.
  • Tissue specificity
    Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 1 F5/8 type C domain.
    Contains 1 protein kinase domain.
  • Domain
    The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates.
  • Cellular localization
    Secreted and Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CAK antibody
    • CD 167 antibody
    • CD167 antibody
    • CD167 antigen-like family member A antibody
    • CD167a antibody
    • Cell adhesion kinase antibody
    • DDR 1 antibody
    • DDR antibody
    • DDR1 antibody
    • DDR1_HUMAN antibody
    • Discoidin domain receptor antibody
    • Discoidin domain receptor tyrosine kinase 1 antibody
    • Discoidin receptor tyrosine kinase antibody
    • Discoidin receptor tyrosine kinase isoform a antibody
    • EDDR 1 antibody
    • EDDR1 antibody
    • Epithelial discoidin domain receptor 1 antibody
    • Epithelial discoidin domain-containing receptor 1 antibody
    • Epithelial specific receptor kinase antibody
    • HGK2 antibody
    • Mammarian carcinoma kinase 10 antibody
    • Mammary carcinoma kinase 10 antibody
    • MCK-10 antibody
    • MCK10 antibody
    • NEP antibody
    • Neuroepithelial tyrosine kinase antibody
    • Neurotrophic tyrosine kinase receptor type 4 antibody
    • NTRK 4 antibody
    • NTRK4 antibody
    • OTTHUMP00000029343 antibody
    • OTTHUMP00000029344 antibody
    • OTTHUMP00000029345 antibody
    • OTTHUMP00000029346 antibody
    • OTTHUMP00000029347 antibody
    • OTTHUMP00000164863 antibody
    • OTTHUMP00000164867 antibody
    • OTTHUMP00000222080 antibody
    • Protein-tyrosine kinase 3A antibody
    • Protein-tyrosine kinase RTK-6 antibody
    • PTK 3 antibody
    • PTK 3A protein tyrosine kinase 3A antibody
    • PTK3 antibody
    • PTK3A antibody
    • Receptor tyrosine kinase NEP antibody
    • RTK 6 antibody
    • RTK6 antibody
    • TRK E antibody
    • TRKE antibody
    • Tyrosine kinase DDR antibody
    • Tyrosine kinase receptor E antibody
    • Tyrosine-protein kinase CAK antibody
    see all

Images

  • Anti-MCK10 antibody (ab155508) at 1/500 dilution + THP1 whole cell lysate at 30 µg

    Predicted band size : 101 kDa
  • Immunohistochemical analysis of paraffin-embedded BT474 xenograft tissue labeling MCK10 with ab155508 at 1/250 dilution.

References

ab155508 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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