Overview

  • Product nameAnti-MCM6 antibody
    See all MCM6 primary antibodies
  • Description
    Goat polyclonal to MCM6
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Horse, Guinea pig, Cow, Dog, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residue 775 and the C-terminus (residue 821) of Human MCM6 (NP_005906.2).

  • Positive control
    • Human colon adenocarcinoma. Mouse squamous cell carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab84293 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Target

  • FunctionActs as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
  • Sequence similaritiesBelongs to the MCM family.
    Contains 1 MCM domain.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus. Binds to chromatin during G1 and detach from it during S phase.
  • Information by UniProt
  • Database links
  • Alternative names
    • DNA replication licensing factor MCM6 antibody
    • MCG40308 antibody
    • Mcm6 antibody
    • MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) antibody
    • MCM6 minichromosome maintenance deficient 6 antibody
    • MCM6_HUMAN antibody
    • Minichromosome maintenance complex component 6 antibody
    • Minichromosome maintenance deficient (mis5 S. pombe) 6 antibody
    • Minichromosome maintenance deficient 6 homolog antibody
    • Minichromosome maintenance protein 6 antibody
    • Mis5 antibody
    • MIS5 homolog antibody
    • p105MCM antibody
    see all

Anti-MCM6 antibody images

  • ab84293, at 1/250 dilution, staining MCM6 in formalin-fixed, paraffin-embedded human colon adenocarcinoma tissue by Immunohistochemistry using DAB detection.
  • ab84293, at 1/250 dilution, staining MCM6 in formalin-fixed, paraffin-embedded mouse squamous cell carcinoma tissue by Immunohistochemistry using DAB detection.

References for Anti-MCM6 antibody (ab84293)

ab84293 has not yet been referenced specifically in any publications.

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