Anti-MCM7 antibody (ab51062)

Overview

• Product name
  Anti-MCM7 antibody
  See all MCM7 primary antibodies
• Description
  Rabbit polyclonal to MCM7
• Tested applications
  Suitable for: IP, WBmore details
  Unsuitable for: ICC/IF
• Species reactivity
  Reacts with: Rat, Human
  Does not react with: Mouse
• Immunogen

  Synthetic peptide corresponding to residues near the N-terminus of human MCM7.

• Positive control
  • HeLa cell lysate.

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage buffer
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Concentration information loading...
• Purity
  Protein A purified
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Synthesis
  • Other

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • HeLa nuclear extract lysate (ab14655)

Applications

Target

• Function
  Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
• Sequence similarities
  Belongs to the MCM family.
  Contains 1 MCM domain.
• Post-translational
  modifications
  Phosphorylated upon DNA damage, probably by ATM or ATR.
• Cellular localization
  Nucleus.

• Target information above from: UniProt accession P33993 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 4176 Human
  • Entrez Gene: 288532 Rat
  • Omim: 600592 Human
  • SwissProt: P33993 Human
  • Unigene: 438720 Human
  • Unigene: 113 Rat
• Alternative names
  • CDABP0042 antibody
  • CDC 47 antibody
  • CDC47 antibody

  • CDC47 homolog antibody
  • Cdc47, S. cerevisiae, homolog of antibody
  • DNA replication licensing factor MCM7 antibody
  • Homolog of S. cerevisiae Cdc47 antibody
  • MCM 2 antibody
  • MCM 7 antibody
  • MCM2 antibody
  • MCM2, formerly antibody
  • Mcm7 antibody
  • MCM7 minichromosome maintenance deficient 7 antibody
  • MCM7_HUMAN antibody
  • Minichromosome Maintainence 7 antibody
  • Minichromosome maintainence, S. cerevisiae, homolog of antibody
  • Minichromosome maintenance complex component 7 antibody
  • Minichromosome maintenance deficient 7 antibody
  • Minichromosome maintenance protein 7 antibody
  • P1.1 MCM3 antibody
  • P1.1-MCM3 antibody
  • P1CDC47 antibody
  • P85MCM antibody
  • PNAS 146 antibody
  • PNAS146 antibody
  • PPP1R104 antibody
  • Protein phosphatase 1, regulatory subunit 104 antibody

  see all

Protocols

• Western blot protocols
• Immunoprecipitation protocols