Overview

  • Product name
  • Description
    Rabbit polyclonal to MCM8
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human MCM8 aa 321-351 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9UJA3

  • Positive control
    • T47D cell line lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab173215 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 94 kDa.

Target

  • Function
    Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle.
  • Tissue specificity
    Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers.
  • Sequence similarities
    Belongs to the MCM family.
    Contains 1 MCM domain.
  • Cellular localization
    Nucleus. Localizes to nuclear foci and colocalizes with RAD51.
  • Information by UniProt
  • Database links
  • Alternative names
    • C20orf154 antibody
    • dJ967N21.5 antibody
    • DNA helicase MCM8 antibody
    • DNA replication licensing factor MCM8 antibody
    • MCM8 antibody
    • MCM8_HUMAN antibody
    • MGC119522 antibody
    • MGC119523 antibody
    • MGC12866 antibody
    • MGC4816 antibody
    • Minichromosome maintenance 8 antibody
    • Minichromosome maintenance complex component 8 antibody
    • REC antibody
    see all

Images

  • Anti-MCM8 antibody (ab173215) at 1/100 dilution + T47D cell line lysate at 35 µg

    Predicted band size: 94 kDa

References

ab173215 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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