Overview

  • Product nameAnti-MCP1 antibody [4E2/MCP] (Biotin)
    See all MCP1 primary antibodies
  • Description
    Armenian Hamster monoclonal [4E2/MCP] to MCP1 (Biotin)
  • ConjugationBiotin
  • SpecificityThis antibody is specific to mouse monocyte chemoattractant protein (MCP-1). The antibody does not react with related mouse beta chemokines, TCA3 and MIP-1 beta.
  • Tested applicationsSuitable for: ELISA, ELISpotmore details
  • Species reactivity
    Reacts with: Mouse
    Does not react with: Human
  • Immunogen

    CHO expressed, recombinant mouse MCP-1.

  • General notes

    The antibody was conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.

Properties

Applications

Our Abpromise guarantee covers the use of ab21397 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use a concentration of 1 - 4 µg/ml.
ELISpot Use at an assay dependent dilution.

Target

  • FunctionChemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
  • Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
  • Post-translational
    modifications
    Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • C-C motif chemokine 2 antibody
    • CCL2 antibody
    • CCL2_HUMAN antibody
    • Chemokine (C C motif) ligand 2 antibody
    • GDCF 2 antibody
    • GDCF-2 antibody
    • GDCF2 antibody
    • HC11 antibody
    • HSMCR30 antibody
    • JE antibody
    • MCAF antibody
    • MCP 1 antibody
    • MCP-1 antibody
    • MCP1 antibody
    • MGC9434 antibody
    • Monocyte chemoattractant protein 1 antibody
    • Monocyte chemotactic and activating factor antibody
    • Monocyte chemotactic protein 1 antibody
    • Monocyte secretory protein JE antibody
    • SCYA2 antibody
    • Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je) antibody
    • Small inducible cytokine A2 antibody
    • Small inducible cytokine subfamily A (Cys Cys), member 2 antibody
    • Small-inducible cytokine A2 antibody
    • SMC CF antibody
    • SMC-CF antibody
    • SMCCF antibody
    see all

References for Anti-MCP1 antibody [4E2/MCP] (Biotin) (ab21397)

This product has been referenced in:
  • Luo Y  et al. Serologic analysis of the mouse beta chemokine JE/monocyte chemoattractant protein-1. J Immunol 153:3708-16 (1994). Read more (PubMed: 7523503) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"