Overview

  • Product name
    Anti-MCP4 antibody [500-M70]
    See all MCP4 primary antibodies
  • Description
    Mouse monoclonal [500-M70] to MCP4
  • Tested applications
    Suitable for: ELISA, Neutralisingmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Highly pure (>98%) recombinant hMCP-4 (human Macrophage/Monocyte chemotactic protein-4).

Properties

  • Form
    Lyophilised:Reconstitute with 500µl of sterile water.
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    PBS, pH 7.4, no preservative, sterile filtered
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Monoclonal
  • Clone number
    500-M70
  • Myeloma
    unknown
  • Isotype
    IgG1
  • Light chain type
    unknown
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab9559 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
Neutralising
  • Application notes
    NEUTRALIZATION:To yield one-half maximal inhibition [ND50] of the biological activity of rMCP-4 (100ng/ml), a concentration of 1-5µg/ml of the antibody is required.

    ELISA:This antibody can be used at a concentration of 1-2µg/ml, as a capture antibody in conjunction with a compatible secondary reagent to yield satisfactory results in a sandwich ELISA (using 100µl/well antibody solution).
  • Target

    • Function
      Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
    • Tissue specificity
      Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.
    • Sequence similarities
      Belongs to the intercrine beta (chemokine CC) family.
    • Post-translational
      modifications
      One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • C-C motif chemokine 13 antibody
      • CCL13 antibody
      • CCL13_HUMAN antibody
      • Chemokine (C C motif) ligand 13 antibody
      • CK beta 10 antibody
      • CK-beta-10 antibody
      • CKb10 antibody
      • MCP-4 antibody
      • MGC17134 antibody
      • Monocyte chemoattractant protein 4 antibody
      • Monocyte chemotactic protein 4 antibody
      • NCC 1 antibody
      • NCC-1 antibody
      • NCC1 antibody
      • New CC chemokine 1 antibody
      • SCYA13 antibody
      • SCYL1 antibody
      • short chain antibody
      • Small inducible cytokine A13 precursor antibody
      • Small inducible cytokine subfamily A (Cys Cys) member 13 antibody
      • Small-inducible cytokine A13 antibody
      see all

    References

    This product has been referenced in:
    • Martin P  et al. Prostate epithelial Pten/TP53 loss leads to transformation of multipotential progenitors and epithelial to mesenchymal transition. Am J Pathol 179:422-35 (2011). Read more (PubMed: 21703421) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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