The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/400. Predicted molecular weight: 52 kDa.
FunctionProton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter.
Tissue specificityHigh expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells.
Sequence similaritiesBelongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.