Overview

  • Product nameAnti-MDC antibody [EP1363Y]
    See all MDC primary antibodies
  • Description
    Rabbit monoclonal [EP1363Y] to MDC
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: Flow Cyt,IHC-P or IP
  • Species reactivity

    Predicted to work with: Mouse
  • Immunogen

    A synthetic peptide corresponding to residues near the C terminus of mouse MDC.

  • Positive control
    • Mouse MDC recombinant protein.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

     

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Human, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
  • PurityTissue culture supernatant
  • ClonalityMonoclonal
  • Clone numberEP1363Y
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab76094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 8 kDa (predicted molecular weight: 10 kDa).
  • Application notesIs unsuitable for Flow Cyt,IHC-P or IP.
  • Target

    • FunctionMay play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.
    • Tissue specificityHighly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.
    • Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
    • Post-translational
      modifications
      The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • A 152E5.1 antibody
      • ABCD 1 antibody
      • ABCD1 antibody
      • C C motif chemokine 22 antibody
      • CC chemokine STCP 1 antibody
      • CC chemokine STCP-1 antibody
      • ccl 22 antibody
      • Ccl22 antibody
      • CCL22_HUMAN antibody
      • Chemokine (C C motif) ligand 22 antibody
      • DC/B CK antibody
      • DCBCK antibody
      • Macrophage-derived chemokine antibody
      • MDC antibody
      • MDC(1-69) antibody
      • MDC(7-69) antibody
      • MGC34554 antibody
      • SCYA22 antibody
      • Small inducible cytokine subfamily A (Cys Cys) member 22 antibody
      • Small inducible cytokine subfamily A, member 22 antibody
      • Small-inducible cytokine A22 antibody
      • STCP 1 antibody
      • STCP1 antibody
      • Stimulated T cell chemotactic protein 1 antibody
      • Stimulated T-cell chemotactic protein 1 antibody
      see all

    Anti-MDC antibody [EP1363Y] images

    • Anti-MDC antibody [EP1363Y] (ab76094) at 1/500 dilution + mouse MDC recombinant protein at 0.005 µg

      Secondary
      Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size : 10 kDa
      Observed band size : 8 kDa (why is the actual band size different from the predicted?)

    References for Anti-MDC antibody [EP1363Y] (ab76094)

    ab76094 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab76094.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"