Overview

  • Product name
    Anti-Measles nucleoprotein antibody
    See all Measles nucleoprotein primary antibodies
  • Description
    Rabbit polyclonal to Measles nucleoprotein
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with Measles virus. Not yet tested in other species.
  • Immunogen

    Recombinant full length protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab23974 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/2000 - 1/10000.
WB 1/200 - 1/1000. Predicted molecular weight: 58 kDa.

Target

  • Relevance
    Involved in the encapsidating of the genome in a ratio of 1 N per 6 ribonucleotides, resulting in the protection from nucleases. The nucleocapsid (NC) has an helical structure with either 12.35 or 11.64 N per turn, approximately 20nm in diameter, with a hollow central cavity approximately 5nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response. Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest
  • Cellular localization
    Virion. Host cytoplasm.
  • Alternative names
    • Measles nucleocapsid protein antibody
    • N antibody
    • NP antibody
    • Nucleocapsid protein antibody

References

This product has been referenced in:
  • Hanauer JR  et al. Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors. Mol Ther Oncolytics 3:16003 (2016). WB . Read more (PubMed: 27119117) »
  • Stewart CE  et al. Inhibitors of the interferon response enhance virus replication in vitro. PLoS One 9:e112014 (2014). Read more (PubMed: 25390891) »

See all 7 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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