Overview

  • Product name
  • Description
    Rabbit polyclonal to Meckelin
  • Tested applications
    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from C terminal domain of human Meckelin.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: Whole serum
  • Purity
    Whole antiserum
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab76786 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration. PubMed: 20512146
WB 1/100 - 1/1000. Predicted molecular weight: 112 kDa.
IHC-P 1/50 - 1/200.

Target

  • Relevance
    Meckelin localizes to the primary cilium and to the plasma membrane. It functions in centriole migration to the apical membrane and formation of the primary cilium. Defects in the gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6).
  • Cellular localization
    Cell membrane; Multi-pass membrane protein
  • Database links
  • Alternative names
    • JBTS6 antibody
    • Meckel syndrome type 3 protein antibody
    • MKS3 antibody
    • NPHP11 antibody
    • TMEM67 antibody
    • TNEM67 antibody
    • Transmembrane protein 67 antibody
    see all

Anti-Meckelin antibody images

References for Anti-Meckelin antibody (ab76786)

This product has been referenced in:
  • Zhang M  et al. A missense mutation in TMEM67 causes Meckel-Gruber syndrome type 3 (MKS3): a family from China. Int J Clin Exp Pathol 8:5379-86 (2015). Read more (PubMed: 26191240) »
  • Valente EM  et al. Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes. Nat Genet : (2010). ICC/IF ; Human . Read more (PubMed: 20512146) »

See all 3 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab76786.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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