Overview

  • Product nameAnti-MED13L antibody
    See all MED13L primary antibodies
  • Description
    Rabbit polyclonal to MED13L
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    A synthesized peptide derived from an internal region of Human MED13L.

  • Positive control
    • Human brain tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab111260 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionComponent of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
  • Tissue specificityHighly expressed in brain (cerebellum), heart (aorta), skeletal muscle, kidney, placenta and peripheral blood leukocytes. Highly expressed in fetal brain.
  • Involvement in diseaseDefects in MED13L are a cause of transposition of the great arteries, dextro-looped (DTGA) [MIM:608808]. DTGA consists of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. Patients often have atrial and/or ventricular septal defects or other types of shunting that allow some mixing between the circulations in order to support life minimally, but surgical intervention is always required.
    Note=A chromosomal aberration involving MED13L is found in a patient with transposition of the great arteries, dextro-looped and mental retardation. Translocation t(12;17)(q24.1;q21).
  • Sequence similaritiesBelongs to the Mediator complex subunit 13 family.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • MD13L_HUMAN antibody
    • MED13L antibody
    • Mediator complex subunit 13 like antibody
    • Mediator complex subunit 13-like antibody
    • Mediator of RNA polymerase II transcription subunit 13-like antibody
    • THRAP2 antibody
    • Thyroid hormone receptor-associated protein 2 antibody
    • Thyroid hormone receptor-associated protein complex 240 kDa component-like antibody
    • TRAP240L antibody
    see all

Anti-MED13L antibody images

  • Immunohistochemistry analysis of paraffin-embedded Human brain tissue, using 1/50 ab111260. The picture on the right is treated with the synthesized peptide

References for Anti-MED13L antibody (ab111260)

ab111260 has not yet been referenced specifically in any publications.

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