Overview

  • Product name
  • Description
    Rabbit polyclonal to MEF2B
  • Tested applications
    Suitable for: WB, EMSA, IPmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 234-365 of Human MEF2B

Properties

Applications

Our Abpromise guarantee covers the use of ab33540 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 39 kDa.
EMSA Use at an assay dependent dilution. Use 0.1µl per sample.
IP Use at an assay dependent dilution. Use 4µl for 1ml cell lysate.

Target

  • Function
    Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
  • Tissue specificity
    Expressed in skeletal and cardiac muscle and brain.
  • Sequence similarities
    Belongs to the MEF2 family.
    Contains 1 MADS-box domain.
    Contains 1 Mef2-type DNA-binding domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • MADS box transcription enhancer factor 2 antibody
    • MDS1 EVI1 antibody
    • Mef2b antibody
    • MEF2B_HUMAN antibody
    • Myocyte enhancer factor 2B antibody
    • Myocyte specific enhancer factor 2B antibody
    • Myocyte-specific enhancer factor 2B antibody
    • PRDM3 antibody
    • RSRFR2 antibody
    • Serum response factor like protein 2 antibody
    • Serum response factor-like protein 2 antibody
    • XMEF2 antibody
    see all

References

This product has been referenced in:
  • Pon JR  et al. MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation. Nat Commun 6:7953 (2015). IP ; Human . Read more (PubMed: 26245647) »
  • Ryan RJ  et al. Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma. Cancer Discov 5:1058-71 (2015). Read more (PubMed: 26229090) »

See all 7 Publications for this product

Customer reviews and Q&As

The immunogen of ab33540 derives from the protein MEF2B isoform b, http://www.ncbi.nlm.nih.gov/protein/5174543. It is originally from the gene RSRFR2 described in Pollack and Treisman, Genes and Development 1991.

The immunogen sequence is aa 2...

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Muchas gracias por tomarte la molestia de mandarnos el cuestionario y las imágenes.

He estudiado el protocolo enviado, y hay una serie de sugerencias que me gustaría haceros para intentar mejorar los resultados del anticuerpo. <...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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