Human Predicted to work with:
Synthetic peptide corresponding to Human MEK3 (phospho T222) conjugated to Keyhole Limpet Haemocyanin (KLH). Peptide sequence around phosphorylation site of threonine 222 (A-K-T(p)-M-D). NP_659731.1. Database link: P46734
Human brain tissue; Jurkat cell extracts, treated with serum.
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Involvement in disease
Note=Defects in MAP2K3 may be involved in colon cancer.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Contains 1 protein kinase domain.
Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.