Anti-MelanA antibody (ab118440)


  • Product nameAnti-MelanA antibody
    See all MelanA primary antibodies
  • Description
    Rabbit polyclonal to MelanA
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide from the C-terminal region of Human MelanA

  • Positive control
    • Human melanoma tissue; Human skin tissue (melanocytes)



Our Abpromise guarantee covers the use of ab118440 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • FunctionInvolved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
  • Tissue specificityExpression is restricted to melanoma and melanocyte cell lines and retina.
  • Post-translational
  • Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus. Golgi apparatus > trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
  • Information by UniProt
  • Database links
  • Alternative names
    • Antigen LB39 AA antibody
    • Antigen LB39-AA antibody
    • Antigen SK29 AA antibody
    • Antigen SK29-AA antibody
    • MAR1_HUMAN antibody
    • MART 1 antibody
    • MART-1 antibody
    • MART1 antibody
    • Melan A antibody
    • Melan A protein antibody
    • Melanoma antigen recognized by T cells 1 antibody
    • Melanoma antigen recognized by T-cells 1 antibody
    • MLAN A antibody
    • MLANA antibody
    • OTTHUMP00000021036 antibody
    • OTTHUMP00000021037 antibody
    • OTTHUMP00000021038 antibody
    • Protein Melan-A antibody
    see all

Anti-MelanA antibody images

  • ab118440 at 10ug/ml staining MelanA in Human melanoma (4 microns) tissue by immunohistochemistry (FFPE). Following primary incubation slides were incubated with biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab118440 at 10ug/ml staining MelanA in Human skin tissue (melanocytes) by immunohistochemistry (FFPE). Following primary incubation slides were incubated with biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-MelanA antibody (ab118440)

ab118440 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

Having checked with the lab, I am sorry to let you know that we are unable to provide these MelanA antibodies in a buffer without BSA.

However, if you need to remove BSA and other unwanted ingredients, I...

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Application Immunohistochemistry (Frozen sections)
Sample Human Tissue sections (Skin)
Permeabilization No
Specification Skin
Blocking step Peroxidase blocking buffer as blocking agent for 10 minute(s) · Concentration: 0.3% · Temperature: RT°C
Fixative Acetone

Abcam user community

Verified customer

Submitted Feb 09 2016

Thank you for your enquiry.

Indeed, the purification kits are designed for cleaning up small volumes of antibodies (ideallyin a volume of 100µl to 0.5ml), as you can see on the datasheet for ab102784.

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