Antagonist at the NMDA receptor. Acts as a fast, voltage-dependent, open channel NMDA receptor blocker. Used in the clinic to treat Alzheimer's disease. Cognitive enhancer and anxiolytic in vivo.
Also available in simple stock solutions (ab146687) - add 1 ml of water to get an exact, ready-to-use concentration.
Store at Room Temperature. The product can be stored for up to 12 months.
Soluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Functional Studies - Memantine hydrochloride (ab120249)Image from Wills TA et al., Proc Natl Acad Sci U S A. 2012;109(5):E278-87. Fig 6(D).; doi: 10.1073/pnas.1113820109.
Averaged time courses of NMDA receptor-isolated synaptic field potentials in dorsal lateral bed nucleus of the stria terminalis following 60 minutes of memantine (5 or 30 μM; ab120249) in naive adult male C57BL/6J mice.