• Product nameAnti-Menin antibody (Agarose)
    See all Menin primary antibodies
  • Description
    Rabbit polyclonal to Menin (Agarose)
  • ConjugationAgarose
  • Tested applicationsSuitable for: IPmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide (Human) (C terminal).

  • General notesAffinity purified antibodies were coupled to agarose beads using a cyanogen bromide method. 100ug of antibody is provided in 200ul of agarose which is in a 400ul volume leading to a final concentration of 0.25 ug/ul in 400ul volume.



Our Abpromise guarantee covers the use of ab19206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIP: 15 to 25ul of gel slurry per 0.1 to 1 mg of protein lysate or extract.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionEssential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
    • Tissue specificityUbiquitous.
    • Involvement in diseaseDefects in MEN1 are the cause of familial multiple endocrine neoplasia type I (MEN1) [MIM:131100]. Autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia.
      Defects in MEN1 are the cause of familial isolated hyperparathyroidism (FIHP) [MIM:145000]; also known as hyperparathyroidism type 1 (HRPT1). FIHP is an autosomal dominant disorder characterized by hypercalcemia, elevated parathyroid hormone (PTH) levels, and uniglandular or multiglandular parathyroid tumors.
    • Post-translational
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationNucleus. Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
    • Information by UniProt
    • Database links
    • Alternative names
      • MEA 1 antibody
      • MEA1 antibody
      • MEN 1 antibody
      • Men1 antibody
      • MEN1_HUMAN antibody
      • Menin antibody
      • Multiple Endocrine Adenomatosis 1 antibody
      • Multiple Endocrine Neoplasia 1 antibody
      • SCG 2 antibody
      • SCG2 antibody
      • Suppressor Candidate Gene 2 antibody
      • Wermer syndrome antibody
      • ZES antibody
      • Zollinger Ellison Syndrome antibody
      see all

    References for Anti-Menin antibody (Agarose) (ab19206)

    ab19206 has not yet been referenced specifically in any publications.

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