Overview

  • Product nameMepyramine maleate
  • Description
    Selective H1 inverse agonist
  • Alternative names
    • Pyrilamine maleate
  • Biological descriptionSelective H1 receptor inverse agonist (Ki = 0.4 nM). Blood-brain barrier permeable. Shows antihistaminergic action. Additionally, inhibits histamine-induced inositol phosphate production and intracellular calcium mobilization.
  • Purity> 99%

Properties

    References for Mepyramine maleate (ab120735)

    This product has been referenced in:
    • Parsons ME & Ganellin CR Histamine and its receptors. Br J Pharmacol 147 Suppl 1:S127-35 (2006). Read more (PubMed: 16402096) »
    • Fitzsimons CP  et al. Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein. J Biol Chem 279:34431-9 (2004). Read more (PubMed: 15192105) »
    • Yamazaki M  et al. Transport mechanism of an H1-antagonist at the blood-brain barrier: transport mechanism of mepyramine using the carotid injection technique. Biol Pharm Bull 17:676-9 (1994). Read more (PubMed: 7920432) »

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