Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceMER is a member of the MER/AXL/SKY receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
SKY may be involved in cell adhesion processes, particularly in the central nervous system. In case of filovirus infection, seems to function as a cell entry factor.
Cellular localizationMembrane; Single-pass type I membrane protein