Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab110108 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/2000.
IHC-P Use a concentration of 3.75 µg/ml.

Target

  • Function
    In case of filovirus infection, seems to function as a cell entry factor.
  • Tissue specificity
    Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
  • Involvement in disease
    Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • c MER antibody
    • c mer proto oncogene tyrosine kinase antibody
    • c-mer antibody
    • cMER antibody
    • cmer protooncogene tyrosine kinase antibody
    • Eyk antibody
    • MER antibody
    • MER receptor tyrosine kinase antibody
    • MERK antibody
    • MERPEN antibody
    • Mertk antibody
    • MERTK c-mer proto-oncogene tyrosine kinase antibody
    • MERTK_HUMAN antibody
    • MGC133349 antibody
    • nmf12 antibody
    • Nyk antibody
    • Proto oncogene tyrosine protein kinase MER antibody
    • Proto oncogene tyrosine protein kinase MER precursor antibody
    • Proto-oncogene c-Mer antibody
    • Receptor tyrosine kinase MerTK antibody
    • RP38 antibody
    • STK kinase antibody
    • Tyrosine-protein kinase Mer antibody
    see all

Anti-MERTK antibody images

  • ab110108 at 3.75 µg/ml staining MERTK in Formalin-Fixed, Paraffin-Embedded Human Adrenal tissue.

References for Anti-MERTK antibody (ab110108)

This product has been referenced in:
  • Jung Y  et al. Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow. Oncotarget 7:25698-711 (2016). Read more (PubMed: 27028863) »

See 1 Publication for this product

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application
Immunohistochemistry (Frozen sections)
Sample
Mouse Tissue sections (hind limb muscle)
Permeabilization
No
Specification
hind limb muscle
Blocking step
BSA as blocking agent for 30 minute(s) · Concentration: 3% · Temperature: 25°C
Fixative
Formaldehyde
Username

Abcam user community

Verified customer

Submitted May 16 2017

Thank you for your enquiry. Sorry for the late reply. Here is the retrieval information you requested: Steam slides in 0.01 M sodium citrate buffer, pH 6.0 at 99-100°C - 20 minutes I hope this is helpful. Please contact us again if you have any f...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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