Overview

  • Product nameAnti-MESDC2 antibody
    See all MESDC2 primary antibodies
  • Description
    Mouse polyclonal to MESDC2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human MESDC2 protein (NP_055969).

  • Positive control
    • MESDC2 transfected 293T cell lysate. Human liver tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab68809 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 25 kDa (predicted molecular weight: 26 kDa).

Target

  • FunctionChaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
  • Sequence similaritiesBelongs to the MESD family.
  • DomainThe chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
    The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.
  • Cellular localizationEndoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • BOCA antibody
    • KIAA0081 antibody
    • LDLR chaperone MESD antibody
    • MESD antibody
    • MESD_HUMAN antibody
    • MESDC 2 antibody
    • mesdc2 antibody
    • Mesoderm development candidate 2 antibody
    • Mesoderm development protein antibody
    • Renal carcinoma antigen NY REN 61 antibody
    • Renal carcinoma antigen NY-REN-61 antibody
    see all

Anti-MESDC2 antibody images

  • Anti-MESDC2 antibody (ab68809) at 1/500 dilution + human liver lysate at 25 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 26 kDa
    Observed band size : 25 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-MESDC2 antibody (ab68809) at 1/500 dilution

    Lane 1 : MESDC2 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 26 kDa
    Observed band size : 26 kDa
    Additional bands at : 23 kDa. We are unsure as to the identity of these extra bands.

References for Anti-MESDC2 antibody (ab68809)

ab68809 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab68809.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"