Anti-MESDC2 antibody - C-terminal (ab170504)

Overview

  • Product name
    Anti-MESDC2 antibody - C-terminal
  • Description
    Rabbit polyclonal to MESDC2 - C-terminal
  • Tested applications
    Suitable for: IHC-P, WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human MESDC2 aa 203-234 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q14696

  • Positive control
    • Hela, 293 and HepG2 cell line lysates, Human stomach tissue, 293 cells

Properties

Applications

Our Abpromise guarantee covers the use of ab170504 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/100 - 1/500. Predicted molecular weight: 26 kDa.
ICC/IF 1/10 - 1/50.

Target

  • Function
    Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
  • Sequence similarities
    Belongs to the MESD family.
  • Domain
    The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
    The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.
  • Cellular localization
    Endoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • BOCA antibody
    • KIAA0081 antibody
    • LDLR chaperone MESD antibody
    • MESD antibody
    • MESD_HUMAN antibody
    • MESDC 2 antibody
    • mesdc2 antibody
    • Mesoderm development candidate 2 antibody
    • Mesoderm development protein antibody
    • Renal carcinoma antigen NY REN 61 antibody
    • Renal carcinoma antigen NY-REN-61 antibody
    see all

Images

  • Immunofluorescent analysis of 293 cells labeling MESDC2 with ab170504 at 1/10 followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green) and DAPI staining.

  • Immunohistochemical analysis of paraffin embedded Human stomach tissue labeling MESDC2 with ab170504 at 1/10.

  • All lanes : Anti-MESDC2 antibody - C-terminal (ab170504) at 1/100 dilution

    Lane 1 : HeLa cell line lysate
    Lane 2 : 293 cell line lysate
    Lane 3 : HepG2 cell line lysate

    Lysates/proteins at 35 µg per lane.


    Predicted band size : 26 kDa

References

ab170504 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab170504.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up