Anti-Mesothelin antibody [PPI-2e(IHC)] (ab92347)


  • Product name
    Anti-Mesothelin antibody [PPI-2e(IHC)]
    See all Mesothelin primary antibodies
  • Description
    Rabbit monoclonal [PPI-2e(IHC)] to Mesothelin
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide corresponding to residues near the C terminus of Human Mesothelin.

  • Positive control
    • Fetal liver, uterus cancer, fetal pancreas and ovary cancer lysates.
  • General notes

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    This antibody detects full-length Mesothelin precursor (69 kDa) and the C terminal cleaved form of Mesothelin.


Associated products


Our Abpromise guarantee covers the use of ab92347 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 69 kDa.Can be blocked with Mesothelin peptide (ab134675).
  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Function
      Membrane-anchored forms may play a role in cellular adhesion.
      Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
    • Tissue specificity
      Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
    • Involvement in disease
      Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
    • Sequence similarities
      Belongs to the mesothelin family.
    • Post-translational
      Both MPF and the cleaved form of mesothelin are N-glycosylated.
      Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
    • Cellular localization
      Secreted and Cell membrane. Golgi apparatus.
    • Information by UniProt
    • Database links
    • Alternative names
      • CAK 1 antibody
      • CAK1 antibody
      • CAK1 antigen antibody
      • cleaved form antibody
      • Megakaryocyte potentiating factor antibody
      • Mesothelin antibody
      • Mesothelin isoform 1 precursor antibody
      • MPF antibody
      • Msln antibody
      • MSLN_HUMAN antibody
      • Pre pro megakaryocyte potentiating factor antibody
      • Pre-pro-megakaryocyte-potentiating factor antibody
      • SMR antibody
      • SMRP antibody
      • Soluble MPF mesothelin related protein antibody
      see all

    Anti-Mesothelin antibody [PPI-2e(IHC)] images

    • All lanes : Anti-Mesothelin antibody [PPI-2e(IHC)] (ab92347) at 1/1000 dilution

      Lane 1 : Fetal liver lysate
      Lane 2 : Uterus cancer lysate
      Lane 3 : Fetal pancreas lysate
      Lane 4 : Ovary cancer lysate

      Lysates/proteins at 10 µg per lane.

      HRP labelled goat anti-rabbit antibody at 1/2000 dilution

      Predicted band size : 69 kDa

    References for Anti-Mesothelin antibody [PPI-2e(IHC)] (ab92347)

    ab92347 has not yet been referenced specifically in any publications.

    Product Wall

    I have good news today.

    We now added the blocking peptide for ab92347 to our catalog and it is available for purchase.

    ab134675 (or use the following:

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    Thank you for your reply.

    I have to confirm that we do not have this peptide in our catalog at the moment. We are trying toadd this toour catalog but Ido not have any estimationwhen this will be available for your customer.

    Your cus...

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