Overview

  • Product name
    Anti-Mesp2 antibody [1B3F9]
    See all Mesp2 primary antibodies
  • Description
    Mouse monoclonal [1B3F9] to Mesp2
  • Host species
    Mouse
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to amino acids 37-94 of Human Mesp2 (UniProt Id: Q0VG99) expressed in E.coli.

  • Positive control
    • Human Mesp2 recombinant protein; Mesp2 (amino acids 37-94)-hIgGFc transfected HEK293 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab166702 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 42 kDa.
ELISA 1/10000.

Target

  • Function
    Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.
  • Involvement in disease
    Defects in MESP2 are the cause of spondylocostal dysostosis type 2 (SCDO2) [MIM:608681]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
  • Sequence similarities
    Contains 1 bHLH (basic helix-loop-helix) domain.
  • Post-translational
    modifications
    Degraded by the proteasome.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Basic helix loop helix protein MESP 2 antibody
    • Basic helix loop helix protein MESP2 antibody
    • BHLH protein MesP2 antibody
    • bHLHc6 antibody
    • Class C basic helix-loop-helix protein 6 antibody
    • Hypothetical class II basic helix loop helix protein MESP 2 antibody
    • Hypothetical class II basic helix loop helix protein MESP2 antibody
    • Mesoderm posterior 2 antibody
    • mesoderm posterior 2 homolog (mouse) antibody
    • Mesoderm posterior 2 homolog antibody
    • Mesoderm posterior protein 2 antibody
    • Mesp 2 antibody
    • MESP2 antibody
    • MESP2_HUMAN antibody
    • SCDO 2 antibody
    • SCDO2 antibody
    see all

Images

  • Anti-Mesp2 antibody [1B3F9] (ab166702) at 1/500 dilution + Human Mesp2 recombinant protein

    Predicted band size: 42 kDa

  • All lanes : Anti-Mesp2 antibody [1B3F9] (ab166702) at 1/500 dilution

    Lane 1 : HEK293 cell lysate
    Lane 2 : Mesp2 (amino acids 37-94)-hIgGFc transfected HEK293 cell lysate

    Predicted band size: 42 kDa

  • ELISA using ab166702 at a 1/10000 dilution.
    Red: Control Antigen (100 ng)
    Purple: Antigen (10 ng)
    Green: Antigen (50 ng)
    Blue: Antigen (100 ng)

References

ab166702 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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