Anti-metabotropic Glutamate Receptor 2 antibody (ab10304)

Product name

Anti-metabotropic Glutamate Receptor 2 antibody
See all Metabotropic Glutamate Receptor 2 products (5) ...

Description

Rabbit polyclonal to metabotropic Glutamate Receptor 2

Tested applications

WBmore details

Cross reactivity

Reacts with

Rat

Predicted to work with

Human

Immunogen

Synthetic peptide: YSRGADGSRHI, corresponding to amino acids 111-120 of Rat metabotropic Glutamate Receptor 2.

YSRGADGSRHI

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Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: 1.0% BSA, Tris-glycine. pH 7.8

Concentration

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Purity

Immunogen affinity purified

Primary antibody notes

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Clonality

Polyclonal

Isotype

IgG

Research areas

Neuroscience >> Neurotransmission >> Receptors / Channels >> GPCR >> Glutamate Receptors