Anti-Metabotropic Glutamate Receptor 5 antibody (ab27190)
Key features and details
- Rabbit polyclonal to Metabotropic Glutamate Receptor 5
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-Metabotropic Glutamate Receptor 5 antibody
See all Metabotropic Glutamate Receptor 5 primary antibodies -
Description
Rabbit polyclonal to Metabotropic Glutamate Receptor 5 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details
Unsuitable for: ICC -
Species reactivity
Reacts with: Human
Predicted to work with: Rabbit -
Immunogen
Synthetic peptide within Human Metabotropic Glutamate Receptor 5 aa 1150 to the C-terminus. The exact sequence is proprietary.
Database link: P41594 -
Positive control
- IHC: human brain tissue.
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General notes
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
This antibody is an affinity purified IgG. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab27190 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
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Notes |
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IHC-P
1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
Target
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Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. -
Sequence similarities
Belongs to the G-protein coupled receptor 3 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 2915 Human
- Omim: 604102 Human
- SwissProt: P41594 Human
- Unigene: 147361 Human
- Unigene: 616625 Human
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Alternative names
- Glutamate receptor metabotropic 5 antibody
- GPRC1E antibody
- Grm5 antibody
see all
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab27190 has been referenced in 8 publications.
- Guo Z et al. Prenatal immune activation potentiates endocannabinoid-related plasticity of inhibitory synapses in the hippocampus of adolescent rat offspring. Eur Neuropsychopharmacol 28:1405-1417 (2018). PubMed: 30257799
- Lum JS et al. A postmortem analysis of NMDA ionotropic and group 1 metabotropic glutamate receptors in the nucleus accumbens in schizophrenia. J Psychiatry Neurosci 43:102-110 (2018). PubMed: 29481317
- Lum JS et al. A postmortem analysis of NMDA ionotropic and group 1 metabotropic glutamate receptors in the nucleus accumbens in schizophrenia. J Psychiatry Neurosci 42:170077 (2017). PubMed: 29022871
- Dai J et al. Improved retinal function in RCS rats after suppressing the over-activation of mGluR5. Sci Rep 7:3546 (2017). PubMed: 28615682
- Matosin N et al. Metabotropic glutamate receptor 5 binding and protein expression in schizophrenia and following antipsychotic drug treatment. Schizophr Res 146:170-6 (2013). PubMed: 23462049
- Gleason KA et al. Susceptibility of the adolescent brain to cannabinoids: long-term hippocampal effects and relevance to schizophrenia. Transl Psychiatry 2:e199 (2012). PubMed: 23188199
- Ma L et al. Differential expression of group I metabotropic glutamate receptors in human motoneurons at low and high risk of degeneration in amyotrophic lateral sclerosis. Neuroscience 143:95-104 (2006). IHC-FoFr ; Human . PubMed: 16979830
- Tang VW Proteomic and bioinformatic analysis of epithelial tight junction reveals an unexpected cluster of synaptic molecules. Biol Direct 1:37 (2006). WB, ICC/IF ; Human . PubMed: 17156438