Anti-Metabotropic Glutamate Receptor 5 antibody (ab76561)

Overview

  • Product nameAnti-Metabotropic Glutamate Receptor 5 antibody
    See all Metabotropic Glutamate Receptor 5 primary antibodies
  • Description
    Mouse monoclonal to Metabotropic Glutamate Receptor 5
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Mouse, Rat, Horse, Chicken, Dog, Human, Chimpanzee
  • Immunogen

    Recombinant fragment: CPGYAGLCDA MKPIDGRKLL ESLMKTNFTG VSGDTILFDE NGDSPGRYEI MNFKEMGKD YFDYINVGSW DNGELKMDDD EVWSKKSNII RSVCSEPCEK G, corresponding to amino acids 419-519 of Human Metabotropic Glutamate Receptor 5 (NP_000833) with a tag of 26 kDa.

  • Positive control
    • Recombinant tagged Human Metabotropic Glutamate Receptor 5 fragment.

Properties

Applications

Our Abpromise guarantee covers the use of ab76561 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 132 kDa.
ELISA Use at an assay dependent dilution. Detection limit for recombinant tagged Metabotropic Glutamate Receptor 5 is approximately 0.03ng/ml as a capture antibody.

Target

  • FunctionG-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 3 family.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Glutamate receptor metabotropic 5 antibody
    • GPRC1E antibody
    • Grm5 antibody
    • GRM5_HUMAN antibody
    • Metabotropic glutamate receptor 5 antibody
    • Metabotropic glutamate receptor 5 variant F antibody
    • Metabotropic glutamate receptor 5 variant G antibody
    • Metabotropic glutamate receptor 5 variant H antibody
    • mGlu5 antibody
    • mGluR5 antibody
    • PPP1R86 antibody
    • Protein phosphatase 1 regulatory subunit 86 antibody
    see all

Anti-Metabotropic Glutamate Receptor 5 antibody images

  • Anti-Metabotropic Glutamate Receptor 5 antibody (ab76561) at 1 µg/ml + Recombinant tagged Human Metabotropic Glutamate Receptor 5 fragment at 0.1 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

    Predicted band size : 132 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)

References for Anti-Metabotropic Glutamate Receptor 5 antibody (ab76561)

ab76561 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"