Biological descriptionPotent 5-HT1, 5-HT2 and 5-HT7 receptor antagonist (Ki = 16 nM at h5-HT7 receptor). Additionally displays activity at dopamine receptors. Elicits cell death.
Chemical name[(8β)-1,6-(Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Knight JA et al. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. Mol Pharmacol75:374-80 (2009).
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