Anti-Methionine Aminopeptidase 2 antibody (ab104665)


  • Product nameAnti-Methionine Aminopeptidase 2 antibody
    See all Methionine Aminopeptidase 2 primary antibodies
  • Description
    Rabbit polyclonal to Methionine Aminopeptidase 2
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide: ATGKKKKKKK KKRGPKVQTD PPSVPICDLY PNGVFPKGQE CEYPPTQDGR , corresponding to a region within internal sequence amino acids 95-144 of Human Methionine Aminopeptidase 2

  • Positive control
    • Human fetal brain cell lysate



Our Abpromise guarantee covers the use of ab104665 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Predicted molecular weight: 53 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use at an assay dependent concentration.


  • FunctionCotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
    Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
  • Sequence similaritiesBelongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
  • Post-translational
    Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
  • Cellular localizationCytoplasm. About 30% of expressed METAP2 associates with polysomes.
  • Information by UniProt
  • Database links
  • Alternative names
    • A930035J23Rik antibody
    • AI047573 antibody
    • AL024412 antibody
    • Amp2 antibody
    • AU014659, antibody
    • EIF 2 associated p67 homolog antibody
    • EIF-2-associated p67 antibody
    • Initiation factor 2 associated 67 kDa glycoprotein antibody
    • Initiation factor 2-associated 67 kDa glycoprotein antibody
    • MAP 2 antibody
    • MAP2 antibody
    • MAP2_HUMAN antibody
    • MetAP 2 antibody
    • Metap2 antibody
    • Methionine aminopeptidase 2 antibody
    • Methionyl aminopeptidase 2 antibody
    • MGC102452 antibody
    • MGC127390 antibody
    • MGC53792 antibody
    • MNPEP antibody
    • p67 antibody
    • p67eIF2 antibody
    • Peptidase M antibody
    • Peptidase M2 antibody
    see all

Anti-Methionine Aminopeptidase 2 antibody images

  • Predicted band size : 53 kDa
    Western blot analysis of Jurkat cell lysate labeling Methionine with ab104665 at 1.0µg/ml.
  • Anti-Methionine Aminopeptidase 2 antibody (ab104665) at 0.5 µg/ml + human fetal brain cell lysate at 10 µg

    Predicted band size : 53 kDa
    Gel concentration 12%
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human small intestine tissue labelling Methionine Aminopeptidase 2 with ab104665.

References for Anti-Methionine Aminopeptidase 2 antibody (ab104665)

ab104665 has not yet been referenced specifically in any publications.

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