Biological descriptionPotent, selective antagonist at α7-containing nicotinic receptors.
Also available in simple stock solutions (ab146684) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name[1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for Methyllycaconitine citrate (MLA) (ab120072)
This product has been referenced in:
Chilton M et al. Behavioral consequences of methyllycaconitine in mice: a model of alpha7 nicotinic acetylcholine receptor deficiency. Life Sci74:3133-9 (2004).
Read more (PubMed: 15081578) »
Davies AR et al. Characterisation of the binding of [3H]methyllycaconitine: a new radioligand for labelling alpha 7-type neuronal nicotinic acetylcholine receptors. Neuropharmacology38:679-90 (1999).
Read more (PubMed: 10340305) »
Whiteaker P et al. An autoradiographic study of the distribution of binding sites for the novel alpha7-selective nicotinic radioligand [3H]-methyllycaconitine in the mouse brain. Eur J Neurosci11:2689-96 (1999).
Read more (PubMed: 10457165) »