Overview

  • Product name
    Mevastatin sodium salt
  • Description
    HMG-CoA reductase inhibitor
  • Biological description
    HMG-CoA reductase inhibitor (IC50 = 119.2 nM). Inhibits cholesterol biosynthesis. Demonstrates pro-apoptotic activity in vivo.
  • Purity
    > 98%

Properties

Applications

Our Abpromise guarantee covers the use of ab120854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.

Images

  • ab90529 staining cytochrome C in HepG2 cells treated with mevastatin sodium salt (ab120854), by ICC/IF. Increase of cytochrome C expression correlates with increased concentration of mevastatin sodium salt, as described in literature.
    The cells were incubated at 37°C for 4 hours in media containing different concentrations of ab120854 (mevastatin sodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab90529 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

References

This product has been referenced in:
  • Zhang S  et al. Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells. Anticancer Drugs 21:678-86 (2010). Read more (PubMed: 20629200) »
  • Perchellet JP  et al. Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins. Int J Mol Med 24:633-43 (2009). Read more (PubMed: 19787197) »
  • Chakravarti R & Sahai V Compactin-a review. Appl Microbiol Biotechnol 64:618-24 (2004). Read more (PubMed: 15034683) »

See 0 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab120854.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up